Chaivation™ blends time-honored botanicals and modern nootropics to support energy, clarity, and cognitive resilience. From adaptogenic mushrooms to dopamine precursors and inflammation-balancing spices, each ingredient has been selected based on its traditional use and emerging evidence for supporting brain and body harmony.

Lion’s Mane mushroom has been studied for its neurotrophic and anti-inflammatory properties and may support brain health by influencing pathways associated with dopamine and serotonin.¹

Mucuna pruriens has a long history of use in Ayurvedic tradition as a vitality tonic and has been studied for its effects on dopamine-related pathways.² It is a natural source of L-Dopa, a direct precursor to dopamine, and has shown potential neuroprotective effects.³ Rich in essential amino acids, Mucuna has also been traditionally used to support male reproductive health.⁴⁻⁶ Studies suggest it may support emotional well-being, a healthy stress response, and a balanced neuroinflammatory state.⁷

Guarana is a natural source of caffeine and theobromine, compounds known for their stimulating properties. It has also been studied for its antioxidant activity and potential metabolic support.⁸⁻⁹

Sunflower lecithin provides phospholipids that support cellular integrity and has been examined for its possible benefits in liver health, metabolic function, and cardiovascular support.¹⁰ It is also a natural source of phosphatidylcholine, a key phospholipid involved in cell membrane structure and choline metabolism.¹¹⁻¹² Phosphatidylcholine contributes to acetylcholine production, a neurotransmitter associated with learning, memory, and cognitive performance. Lecithin has also been shown to enhance the bioavailability of certain compounds, including curcumin, by improving absorption.¹³

Curcumin, the primary active compound in turmeric, has been widely researched for its antioxidant and anti-inflammatory effects, along with its potential role in supporting metabolic and cellular health.¹⁴ Curcumin and related curcuminoids may also support cognitive function, potentially through mechanisms that influence acetylcholine levels.¹⁵⁻¹⁶ Additionally, curcumin has shown promise in supporting cellular resilience and protecting against oxidative stress.¹⁷

Ginger has been studied for its cognitive benefits and its potential to support brain health and a balanced neuroinflammatory response.¹⁸⁻²⁰ It is also known for its antioxidant and anti-inflammatory actions and has a long-standing traditional use in easing occasional nausea and digestive discomfort.²¹

Piperine, the active compound in black pepper, has been studied for its potential to support brain health, metabolic function, and a healthy inflammatory response.²²⁻²³

Studies comparing combinations of ginger, black pepper, and turmeric extracts with conventional agents suggest they may offer supportive benefits for joint comfort and inflammatory balance.²⁴

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2. Lampariello L, Cortelazzo A, Guerranti R, Sticozzi C, Valacchi G. The magic velvet bean of mucuna pruriens. Article. Journal of Traditional and Complementary Medicine. 2012;2(4):331-339. doi:10.1016/S2225-4110(16)30119-5

3. Natarajan K, Narayanan N, Ravichandran N. Review on "Mucuna" - The wonder plant. Review. International Journal of Pharmaceutical Sciences Review and Research. 2012;17(1):86-93.

4. Yadav MK, Upadhyay P, Purohit S, Pandey BL, Shah H. Phytochemistry and pharmacological activity of Mucuna pruriens: A review. Review. International Journal of Green Pharmacy. 2017;11(2):69-73.

5. Adebowale YA, Adeyemi A, Oshodi AA. Variability in the physicochemical, nutritional and antinutritional attributes of six Mucuna species. Article. Food Chemistry. 2005;89(1):37-48. doi:10.1016/j.foodchem.2004.01.084

6. Shukla KK, Mahdi AA, Ahmad MK, Shankhwar SN, Rajender S, Jaiswar SP. Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis. Fertil Steril. Dec 2009;92(6):1934-40. doi:10.1016/j.fertnstert.2008.09.045

7. Tavares RL, Vasconcelos MHA, Dutra M, et al. Mucuna pruriens Administration Minimizes Neuroinflammation and Shows Anxiolytic, Antidepressant and Slimming Effects in Obese Rats. Molecules. Nov 26 2020;25(23)doi:10.3390/molecules25235559

8. Torres E, Pinaffi-Langley A, Figueira MS, et al. Effects of the consumption of guarana on human health: A narrative review. Compr Rev Food Sci Food Saf. Jan 2022;21(1):272-295. doi:10.1111/1541-4337.12862

9. Marques LL, Panizzon GP, Aguiar BA, et al. Guaraná (Paullinia cupana) seeds: Selective supercritical extraction of phenolic compounds. Food Chem. Dec 1 2016;212:703-11. doi:10.1016/j.foodchem.2016.06.028

10. Butina EA, Gerasimenko EO, Bugaets IA, Dubrovskaia IA. Comparative analysis of the physiological value of lecithins obtained from different types of raw materials. Article. Journal of Pharmaceutical Sciences and Research. 2017;9(12):2493-2497.

11. Lončarević I, Pajin B, Petrović J, et al. The impact of sunflower and rapeseed lecithin on the rheological properties of spreadable cocoa cream. Journal of Food Engineering. 2016/02/01/ 2016;171:67-77. doi:https://doi.org/10.1016/j.jfoodeng.2015.10.001

12. Böckmann KA, Franz AR, Minarski M, et al. Differential metabolism of choline supplements in adult volunteers. Eur J Nutr. Feb 2022;61(1):219-230. doi:10.1007/s00394-021-02637-6

13. Chen LC, Chen YC, Su CY, Wong WP, Sheu MT, Ho HO. Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin. Sci Rep. Nov 16 2016;6:37122. doi:10.1038/srep37122

14. Abd El-Hack ME, El-Saadony MT, Swelum AA, et al. Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability. J Sci Food Agric. Nov 2021;101(14):5747-5762. doi:10.1002/jsfa.11372

15. Ahmed T, Enam SA, Gilani AH. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience. Sep 1 2010;169(3):1296-306. doi:10.1016/j.neuroscience.2010.05.078

16. Ahmed T, Gilani AH. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem Behav. Feb 2009;91(4):554-9. doi:10.1016/j.pbb.2008.09.010

17. Hosseini A, Hosseinzadeh H. Antidotal or protective effects of Curcuma longa (turmeric) and its active ingredient, curcumin, against natural and chemical toxicities: A review. Biomed Pharmacother. Mar 2018;99:411-421. doi:10.1016/j.biopha.2018.01.072

18. Arcusa R, Villaño D, Marhuenda J, Cano M, Cerdà B, Zafrilla P. Potential Role of Ginger (Zingiber officinale Roscoe) in the Prevention of Neurodegenerative Diseases. Front Nutr. 2022;9:809621. doi:10.3389/fnut.2022.809621

19. Schepici G, Contestabile V, Valeri A, Mazzon E. Ginger, a Possible Candidate for the Treatment of Dementias? Molecules. Sep 21 2021;26(18)doi:10.3390/molecules26185700

20. Talebi M, İlgün S, Ebrahimi V, et al. Zingiber officinale ameliorates Alzheimer's disease and Cognitive Impairments: Lessons from preclinical studies. Biomed Pharmacother. Jan 2021;133:111088. doi:10.1016/j.biopha.2020.111088

21. Bischoff-Kont I, Fürst R. Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes. Pharmaceuticals (Basel). Jun 15 2021;14(6)doi:10.3390/ph14060571

22. da Cruz GMP, Felipe CFB, Scorza FA, et al. Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms. Pharmacology Biochemistry and Behavior. 2013/03/01/ 2013;104:144-153. doi:https://doi.org/10.1016/j.pbb.2013.01.002

23. Haq I-U, Imran M, Nadeem M, Tufail T, Gondal TA, Mubarak MS. Piperine: A review of its biological effects. https://doi.org/10.1002/ptr.6855. Phytotherapy Research. 2021/02/01 2021;35(2):680-700. doi:https://doi.org/10.1002/ptr.6855

24. Heidari-Beni M, Moravejolahkami AR, Gorgian P, Askari G, Tarrahi MJ, Bahreini-Esfahani N. Herbal formulation "turmeric extract, black pepper, and ginger" versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial. Phytother Res. Aug 2020;34(8):2067-2073. doi:10.1002/ptr.6671